Eric J. Toone
h2.
Research interests include Chemical Biology, Glycobiology, Membrane Biochemistry, Natural Products.
Contact Information
Office Number: (919) 681-3484
e-mail eric.toone@duke.edu
Lab Location
Education
Research Interests
Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide.
Lab Members
Recent Publications
1. Fullerton, S.W. B.; Griffiths, J.S.; Merkel, A.B.; Wymer, N.J.; Hutchins, M.J.; Fierke, C.A.; Toone, E.J.; Naismith, J.H., “Mechanism of the class 1 KDPG aldolase”, Bioorg. Med. Chem., 2005 (IN PRESS.). More…
2. Mori, T.; Hatano, K.; Matsuoka, K.; Esumi, Y.; Toone, E.J.; Terunuma, D., “Synthesis of Carbosilane Dendrimers Having Peripheral Mannose and Mannobiose”, Tetrahedron, 2005, 61, 2751-2760. More…
3. Winter, A.M.; Baron, R.A.; Wong, W.; dela Cruz, J.; York, J.D.; Gooden, D.M.; Toone, E.J.; Casey, P.J., “A small molecule inhibitor of isoprenylcysteine carboxylmethyl transferase with antitumor activity in cancer cells”, Proc. Natl. Acad. Sci. USA, 2005, 102(12), 4336-4341. More…
4. Gooden, D.M.; Chakrapani, H.; Toone, E.J., “C-nitroso compounds: Synthesis, physicochemical properties and biological activities”, Cur. Top. Med. Chem., 2005, 5(7), 687-706. More…
5. Zhao, Y.-L.; McCarren, P.R.; Houk, K.N.; Choi, B.Y.; Toone, E.J., “Nitrosonium-Catalyzed Decomposition of S-Nitrosothiols: A Theoretical and Experimental Study”, J. Am. Chem. Soc., 2004, 127(31), 10917-10924. More…
6. Griffith, J.S,; Cheriyan, M.; Corbell, J.B.; Pocivavsek, L.: Fierke, C.A.; Toone, E.J., “A bacterial selection for the directed evolution of pyruvate aldolases”, Bioorg. Med. Chem., 2004, 12, 4067-4074. More…
7. Christensen, T.; Gooden, D.M.; Kung, J.E.; Nasas, J.I.; Toone, E.J., “Additivity and the Physical Basis of Multivalency Effects. Thermodynamic Investigation of Metal Ion Binding”, J. Am. Chem. Soc., 2003, 125, 7357-7366. More…